Holtercare-Bench: New Multimodal Benchmark for Long-Term ECG Analysis

Yihan Xie, Hanwen Cui, Runze Ye, Juekai Lin, Haoyang Wang, Jinhao Mao, Bo Zhang, Wenqiao Zhang, Xiaogang Guo, Jun Xiao, Lei Zhang· August 21, 2026 View original

Key takeaways

  • Current MLLMs struggle with long-term dynamic ECG analysis due to data and benchmark limitations.
  • Holtercare-23K is a new large-scale, tri-modal dataset for dynamic ECGs.
  • Holtercare-Bench provides a benchmark for temporal localization, diagnosis, and summarization.
  • Fine-tuning MLLMs on this dataset significantly improves performance in electrophysiology.

Who benefits

HealthcareMedical DevicesAI/ML EngineeringPharmaceuticalsTelemedicine

Summary

This paper introduces Holtercare-Bench, a new multimodal benchmark and dataset (Holtercare-23K) for evaluating MLLMs in long-term dynamic ECG analysis. It highlights current MLLM limitations in processing ultra-long pathological sequences and provides a foundation for developing advanced medical MLLMs.

Multimodal large language models (MLLMs) have shown promise in medical applications, but they often struggle with dynamic, long-term signals like electrocardiograms (ECGs). This limitation stems from a scarcity of high-quality datasets and benchmarks specifically designed for complex temporal reasoning and diagnostic report generation in this domain. To address this critical gap, researchers have developed two key resources. First, they introduce Holtercare-23K, a large-scale multimodal dynamic ECG dataset. This dataset comprises 22,980 question-answer pairs derived from 788 clinical Holter records, uniquely featuring a novel signal-video-text tri-modal alignment. This rich data provides a comprehensive foundation for training and evaluating MLLMs. Second, based on this dataset, they present Holtercare-Bench, a multimodal benchmark designed to rigorously evaluate models across three crucial tasks: temporal localization of events, clinical diagnosis, and global summarization of ECG findings. Initial zero-shot evaluations of leading MLLMs on Holtercare-Bench revealed significant performance deficiencies when processing ultra-long pathological sequences. However, subsequent fine-tuning of representative models demonstrated substantial improvements, underscoring the potential for specialized training. This work not only illuminates the current limitations of MLLMs in electrophysiology but also establishes a foundational benchmark for advancing long-term medical MLLMs.

Why it matters

For healthcare professionals, medical AI developers, and researchers, Holtercare-Bench provides a crucial tool to advance AI capabilities in analyzing complex, long-term physiological data, leading to more accurate diagnoses and improved patient care.

How to implement this in your domain

  1. 1Utilize Holtercare-Bench to evaluate the performance of existing or new MLLMs for dynamic ECG analysis.
  2. 2Develop and fine-tune MLLMs specifically on the Holtercare-23K dataset to improve temporal reasoning and diagnostic capabilities.
  3. 3Integrate multimodal data (signal, video, text) into medical AI training pipelines for comprehensive analysis.
  4. 4Collaborate with medical professionals to validate AI diagnoses and ensure clinical relevance.
  5. 5Explore novel MLLM architectures capable of processing and reasoning over ultra-long temporal sequences more effectively.

Original post by Yihan Xie, Hanwen Cui, Runze Ye, Juekai Lin, Haoyang Wang, Jinhao Mao, Bo Zhang, Wenqiao Zhang, Xiaogang Guo, Jun Xiao, Lei Zhang

"arXiv:2608.19297v1 Announce Type: new Abstract: While multimodal large language models (MLLMs) excel in medical applications, most of them favor static images or short-term signals. In the critical field of dynamic electrocardiograms (ECG), models struggle with complex temporal r…"

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Originally posted by Yihan Xie, Hanwen Cui, Runze Ye, Juekai Lin, Haoyang Wang, Jinhao Mao, Bo Zhang, Wenqiao Zhang, Xiaogang Guo, Jun Xiao, Lei Zhang on X · view source

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