LLMs Fabricate Confident Answers on Uninformative Clinical Data

Sagnik De, Sreenija Pavuluri· August 28, 2026 View original

Key takeaways

  • LLM refusal to answer is not always indicative of robustness against hallucination.
  • Prompting style significantly impacts LLM abstention and fabrication behavior.
  • Some LLMs can confidently fabricate answers even when data is provably uninformative.
  • Rigorous testing with uninformative data is crucial for evaluating LLM reliability in sensitive domains.

Who benefits

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Summary

A study evaluated seven LLMs on clinical pain speech transcripts, finding that while most abstained on provably uninformative data under cooperative prompts, some models (Gemini 2.5 Flash, Llama 3.1 8B) consistently fabricated confident pain scores when forced to answer. This highlights that refusal behavior is prompt-dependent and not equivalent to robustness against hallucination.

Benchmarking Large Language Models (LLMs) for hallucination and abstention often fails to establish whether the model truly lacked the information to provide a correct answer, making it hard to differentiate appropriate refusal from unsupported predictions. This research addresses this by evaluating seven LLMs on the TAME Pain speech corpus, which includes transcripts provably uninformative for pain assessment. The corpus contained "no signal" utterances where pain information was only present in acoustic features, not the transcript, and "signal" utterances with explicit pain ratings. Under cooperative prompting, most LLMs correctly abstained on the uninformative transcripts and accurately extracted pain ratings from signal data. However, when prompted with an "authority-framed" tone, abstention became highly prompt-dependent, with some models' refusal rates varying drastically. Critically, when forced to answer, Gemini 2.5 Flash and Llama 3.1 8B exhibited high rates of confident fabrication, generating pain scores with high confidence even when the transcript provided no evidence. This demonstrates that a model's refusal to answer is not necessarily an indicator of robustness against hallucination, and that prompt design significantly influences this behavior, especially in sensitive clinical contexts.

Why it matters

Professionals deploying LLMs in sensitive or critical applications, especially in healthcare, must understand that model refusal is not always a sign of robustness and that prompt engineering can significantly influence hallucination and confident fabrication, necessitating rigorous testing.

How to implement this in your domain

  1. 1Design rigorous evaluation benchmarks for LLMs that include provably uninformative data to test for confident fabrication.
  2. 2Test LLM behavior under various prompting styles, including "authority-framed" prompts, to assess robustness and refusal consistency.
  3. 3Implement mechanisms to detect and flag confidently fabricated responses from LLMs, especially in safety-critical applications.
  4. 4Educate prompt engineers and developers on the nuances of LLM refusal behavior and the risks of prompt-dependent hallucination.

Original post by Sagnik De, Sreenija Pavuluri

"arXiv:2608.26167v1 Announce Type: new Abstract: Hallucination and abstention benchmarks rarely establish that a model could not have known the correct answer, making it difficult to distinguish appropriate abstention from an unsupported prediction. Seven large language models wer…"

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