ReTA Framework Dynamically Augments EHR Data with External Knowledge

Chen Chen, Mohsen Nayebi Kerdabadi, Dongjie Wang, Mei Liu, Zijun Yao· September 3, 2026 View original

Key takeaways

  • ReTA dynamically augments EHR graphs with external knowledge using reinforcement learning.
  • It improves longitudinal prediction tasks like diagnosis and mortality prediction.
  • The framework is efficient, interpretable, and adaptable across datasets and KGs.
  • Dynamic, context-aware knowledge import significantly boosts accuracy, especially with sparse data.

Who benefits

HealthcarePharmaceuticalsMedical ResearchHealth InsuranceBiotech

Summary

ReTA, a reinforcement learning-based framework, dynamically augments Electronic Health Record (EHR) graphs with external knowledge graphs (KGs) on a per-visit, budget-aware basis. It significantly improves longitudinal prediction tasks like diagnosis and mortality prediction while remaining efficient and interpretable.

Longitudinal prediction using Electronic Health Records (EHRs) is often hampered by the inherent sparsity and irregularity of patient data. Augmenting EHR graphs with external knowledge graphs (KGs) offers a promising solution, but existing methods typically apply fixed, context-agnostic augmentations, adding the same KG nodes regardless of a patient's evolving condition. This research introduces ReTA (Reinforcement learning-based dynamic Topology Augmentation), a novel framework that treats KG import as a per-visit, budget-aware policy decision. ReTA first creates a refined pool of KG-grounded templates offline. Then, it learns a policy to select one of three augmentation actions for each patient visit: "Soft Import" (enriching node features), "Hard Import" (grafting a compact KG subgraph), or "Skip" (leaving the visit unaugmented if the base encoder is already confident). To ensure stable learning, ReTA employs a decoupled encoder that processes semantic and structural signals separately before fusing them. Experiments on MIMIC-III and MIMIC-IV datasets for tasks like diagnosis prediction, mortality, and readmission consistently show ReTA outperforming strong baselines. It remains efficient, transfers across datasets and KGs, and provides interpretable augmentation patterns, highlighting the benefits of dynamic, context-aware knowledge integration, especially under sparse supervision.

Why it matters

Healthcare professionals and AI developers can use ReTA to build more accurate and robust predictive models from sparse EHR data, leading to improved patient outcomes, better resource allocation, and more informed clinical decisions.

How to implement this in your domain

  1. 1Evaluate ReTA's dynamic knowledge augmentation approach for existing EHR-based predictive analytics projects.
  2. 2Develop a proof-of-concept to integrate external medical knowledge graphs with patient data using ReTA.
  3. 3Collaborate with clinical experts to define relevant knowledge graph templates and augmentation policies.
  4. 4Benchmark ReTA's performance against static knowledge augmentation methods in real-world healthcare scenarios.

Original post by Chen Chen, Mohsen Nayebi Kerdabadi, Dongjie Wang, Mei Liu, Zijun Yao

"arXiv:2609.01839v1 Announce Type: new Abstract: Longitudinal prediction from electronic health records (EHRs) is limited by the sparsity and irregularity in patient trajectories, and knowledge augmentation with external knowledge graphs (KGs) offers a promising way to alleviate t…"

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Originally posted by Chen Chen, Mohsen Nayebi Kerdabadi, Dongjie Wang, Mei Liu, Zijun Yao on X · view source

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