Omni-Sleep: A Foundation Model for Sleep Analysis Using CNS-ANS Dynamics

Zhoujie Hou, Song Wang, Kexin Lou, Mo Wang, Chen Wei, Quanying Liu· July 10, 2026 View original

Summary

Researchers introduce Omni-Sleep, a sleep foundation model that leverages the physiological organization of central and autonomic nervous systems for representation learning. Pre-trained on over 100,000 hours of multimodal polysomnography data, it outperforms existing baselines in sleep staging and multi-disease classification.

A new sleep foundation model, Omni-Sleep, has been developed to improve the analysis of sleep physiology. Unlike previous models that treat biosignals uniformly, Omni-Sleep incorporates the distinct yet coordinated dynamics of the central nervous system (CNS) and autonomic nervous system (ANS) as a physiological prior. This approach allows for more structured representation learning. The model was trained on an extensive dataset of over 100,000 hours of multimodal polysomnography data, including EEG, EOG, EMG, ECG, and respiration. Omni-Sleep employs three key objectives: ensuring consistency within CNS and ANS subsystems, synchronizing trajectories between these systems to model brain-body dynamics, and using masked temporal modeling for long-horizon sleep patterns. Evaluations show Omni-Sleep surpasses current foundation model baselines in tasks like sleep staging and multi-disease classification. It demonstrates improved label efficiency, better generalization across different datasets, and enhanced robustness to missing data modalities, underscoring the benefits of integrating physiological hierarchy into sleep representation learning.

Why it matters

This research offers a more accurate and robust method for analyzing sleep, potentially leading to earlier and more precise diagnosis of sleep disorders and related health conditions. Professionals in healthcare and AI development can leverage this model for advanced diagnostic tools and personalized medicine.

How to implement this in your domain

  1. 1Explore the open-source code to understand the model's architecture and implementation details.
  2. 2Integrate Omni-Sleep into existing sleep study analysis pipelines for enhanced diagnostic capabilities.
  3. 3Validate the model's performance on specific patient populations or clinical datasets relevant to your practice.
  4. 4Collaborate with researchers to extend the model's application to other physiological signal analysis tasks.

Who benefits

HealthcarePharmaceuticalsMedical DevicesAI/ML Development

Key takeaways

  • Omni-Sleep is a new sleep foundation model using CNS/ANS physiological priors.
  • It improves sleep staging and multi-disease classification accuracy.
  • The model shows better label efficiency and robustness to missing data.
  • Integrating physiological hierarchy enhances generalizable sleep representation learning.

Original post by Zhoujie Hou, Song Wang, Kexin Lou, Mo Wang, Chen Wei, Quanying Liu

"arXiv:2607.07720v1 Announce Type: new Abstract: Sleep physiology arises from the coordinated dynamics of the central nervous system (CNS) and autonomic nervous system (ANS), as reflected by multimodal polysomnography signals including EEG, EOG, EMG, ECG, and respiration. However,…"

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Originally posted by Zhoujie Hou, Song Wang, Kexin Lou, Mo Wang, Chen Wei, Quanying Liu on X · view source

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